![]() investigated the effects of a commercial product containing 100 mg of ecdysteroids on strength and muscle mass of athletes. It has been used for its benefits on muscle strength, muscle pain, and heart protection. turkestanica, a plant native from Uzbekistan, is rich in ecdysteroids, including turkesterone and 20-hydroxyecdysone (20-HE). However, there is limited scientific evidence about their efficacy and safety, and a very few studies have investigated their effects on sarcopenia.Ī. Particularly, dry extracts obtained from the Eurasian plants Ajuga turkestanica, Eurycoma longifolia, and Urtica dioica have been used for this end worldwide. The association of selected herbal extracts has been employed as supplements to increase muscle mass gain, based on their folk use as anabolic agents. Herbal medicine involves the use of the plant alone or in combination with other plants that have complementary properties. Phytotherapy represents an attractive option to treat several diseases and has been used for sarcopenia prevention and maintenance of hormonal levels. Current treatments are focused on hormone replacement therapy, which might display adverse effects including exacerbation of sleep apnea, delayed wound healing, gynecomastia, increased volume of red blood cells, higher risk of cardiovascular diseases and cancer, besides virilization in women. Various drugs and supplements have emerged to treat sarcopenia, such as antioxidant supplementation, vitamin D, ursolic acid, angiotensin-converting enzyme inhibitors, melatonin, ghrelin, dehydroepiandrosterone (DHEA), and selective androgen receptor modulators (SARMS). Nutritional intervention and physical exercise are valuable alternatives for prevention and management of sarcopenia. Sarcopenia is characterized by a progressive reduction in muscle quantity and quality, leading to impaired movement, lessened strength, with an increased risk of injuries secondary to falls, being often associated with frailty. We provide novel data that tested ergogenic extracts, when combined with resistance exercise, improved early sarcopenia alterations in castrated male and female mice.ĭeclining of hormonal levels in aging is a predictor factor for the onset of skeletal muscle loss and related diseases, such as sarcopenia. #Orx animal plus#Resistance exercise plus herbal extracts partly altered gastrocnemius fiber size frequencies in OVX or ORX mice. longifolia or TLU also reduced the ladder climbing time in ORX mice. turkestanica enhanced the grip strength in ORX mice. Exercise combined with TLU improved resistance to fatigue in OVX animals, though A. General physical activity was improved by exercise plus herbal extracts in either OVX or ORX animals. Orchiectomy (ORX) caused skeletal muscle weight loss, accompanied by increased adiposity, being the latter parameter reduced by exercise plus E. dioica extract, or by exercise and TLU, respectively. Ovariectomy (OVX) led to body weight increase and non-high-density cholesterol (HDL) cholesterol elevation, which had been restored by exercise plus U. To assess their actions on early sarcopenia signs, male and female castrated mice were supplemented with lyophilized extracts of the three plants, isolated or in association (named TLU), and submitted to resistance exercise. Dry extracts from the Eurasian plants, Ajuga turkestanica, Eurycoma longifolia, and Urtica dioica have been used as anabolic supplements, despite the limited scientific data on these effects. ![]()
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